Open in a separate window FW: Here, we review major clinical and experimental evidence underlining the pharmacological properties of oleuropein on human health. In addition, we provide original data on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease NAFLD. Effects of Oleuropein on Human Health 2. Antioxidant Effect The antioxidant effect of oleuropein is exerted through different mechanisms, resulting in an enhancement of the antioxidant response [ 2 , 29 ]. Oleuropein has a protective effect in counteracting low-density lipoprotein LDL oxidation, both in vitro, inhibiting, in a dose-dependent manner, LDL copper-induced oxidation [ 31 , 32 ], and in vivo, reducing plasmatic levels of total, free and ester cholesterol in rabbits [ 33 ].
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